Pharmacology: Pharmacokinetics: The single- and multiple-dose pharmacokinetics of escitalopram are linear and dose-proportional in a dose range of 10-30 mg/day. Biotransformation of escitalopram is mainly hepatic with a mean terminal t½ of about 27-32 hrs. With once daily dosing, steady-state plasma concentrations are achieved within approximately 1 week. At steady-state, the extent of accumulation of escitalopram in plasma in young healthy subjects was 2.2-2.5 times the plasma concentrations observed after a single dose. The tablet and the oral solution dosage forms of escitalopram oxalate are bioequivalent.