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Incompatibilities: Heparin and Reteplase are incompatible when combined in solution. Do not administer heparin and Reteplase simultaneously in the same intravenous line.
If Reteplase is to be injected through an intravenous line containing heparin, a normal saline or 5% dextrose (D5W) solution should be flushed through the line prior to and following the Reteplase injection.
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