Mersa IV 500/Mersa IV 1000 Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Vancomycin HCl

Indications/Uses

Life-threatening infections due to susceptible gm +ve organisms which cannot be treated by penicillins & cephalosporins. Severe Staph infections in patients who cannot receive or who have failed to respond to the penicillins & cephalosporins or who have infections w/ Staph that are resistant to other antibiotics. Endocarditis & prophylaxis against endocarditis in patients at risk from dental or surgical procedures. Osteomyelitis, pneumonia, septicemia & soft tissue infections.

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Dosage/Direction for Use

IV infusion Adult 500 mg every 6 hr or 1 g every 12 hr over 60 min. Childn >1 mth 10 mg/kg per dose every 6 hr over 60 min. Infant Initially 15 mg/kg, followed by 10 mg/kg every 12 hr for neonates in 1st wk of life & thereafter every 8 hr up to 1 mth over 60 min.

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Overdosage

View Mersa IV 500/Mersa IV 1000 overdosage for action to be taken in the event of an overdose.

Contraindications

Hypersensitivity. History of shock.

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Warnings

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Special Precautions

Hearing loss. Avoid long-term therapy. Colitis, severe diarrhea. Thrombophlebitis may occur w/ high conc IV administration. Avoid rapid infusion as may cause hypotension. Do not mix w/ drug w/ alkaline soln & w/ β-lactam antibiotics. Impaired vestibular organ or cochlea. Renal impairment. Pregnancy & lactation. Elderly. Premature infant, neonate & toddler.

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Use In Pregnancy & Lactation

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Adverse Reactions

Red man syndrome. Inj site pain & swelling or blood vessel inflammation. Dizziness, tinnitus, hearing loss. Increased bilirubin, AST, ALT & ALP. Increase BUN & creatinine. Exfoliative dermatitis, bullous dermatitis, Stevens-Johnson syndrome & toxic epidermal necrolysis. Rash, erythema, flushing, hypotension, wheezing, dyspnea, urticaria & pruritus. Pseudomembranous colitis.

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Drug Interactions

Increased risk of renal or hearing impairment w/ ethacrynic acid, aminoglycosides, bacitracin, polymixin B or colistin, viomycin, amphotericin B, cisplatin or neuromuscular blockers. Increased frequency of anaphylactoid reaction w/ anesth agents. May increase adverse reactions w/ potentially neurotoxic drugs eg, amphotericin B, aminoglycosides, bacitracin, polymyxin B, colistin, viomycin & platinum antitumor drugs (cisplatin, nedaplatin). Increased anticoagulant activity w/ anticoagulant.

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Caution For Usage

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Storage

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Description

View Mersa IV 500/Mersa IV 1000 description for details of the chemical structure and excipients (inactive components).

Action

View Mersa IV 500/Mersa IV 1000 mechanism of action for pharmacodynamics and pharmacokinetics details.

MIMS Class

Other Antibiotics

ATC Classification

J01XA01 - vancomycin ; Belongs to the class of glycopeptide antibacterials. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Mersa IV 1000 powd for inj 1 g

Packing/Price

1's (P2,301.6/box)

Form

Mersa IV 500 powd for inj 500 mg

Packing/Price

1's (P1,491/box)

Mersa IV 500/Mersa IV 1000

vancomycin

Manufacturer:

Cathay Drug

Distributor:

Cathay Drug