Meptin Drug Interactions

Precautions for co-administration should be administered with care when co-administered with the following drugs: Catecholamines (eg, epinephrine and isoproterenol): The combined use of Meptin with catecholamines may cause arrhythmias or cardiac arrest. Epinephrine, isoproterenol and other catecholamines potentiate the adrenoreceptor stimulating action of Meptin, possibly resulting in the induction of arrhythmias.
Xanthine derivatives (eg, theophylline, aminophylline hydrate and diprophylline): The combined use of xanthine derivatives may aggravate hypokalemia and cardiovascular adverse reactions (eg, tachycardia, arrhythmias) due to β-adrenergic stimulation. If any of these abnormalities are observed, the dose should be reduced or treatment should be discontinued immediately. Xanthine derivatives potentiate the adrenoreceptor-stimulating action of Meptin, possibly resulting in a decrease in serum potassium levels and causing cardiac or vascular adverse reactions. The mechanism responsible for the induction of hypokalemia is not known.
Corticosteroids (eg, betamethasone, prednisolone and hydrocortisone sodium succinate) and diuretics (eg, furosemide): The combined use of Meptin with corticosteroids and diuretics may cause a decrease in serum potassium levels, resulting in arrhythmias. If any of these abnormalities are observed, the dose of the drug should be reduced or treatment should be discontinued immediately. Corticosteroids and diuretics augment the excretion of potassium from the renal tubules, possibly resulting in an excessive decrease in serum potassium levels.