Megapime Hospi Dosage/Direction for Use

The recommended adult and pediatric dosages and routes of administration are outlined in the following table. Cefepime should be administered intravenously over approximately 30 minutes. (See Table 4.)

Click on icon to see table/diagram/image

Patients with Hepatic Impairment: No adjustment is necessary for patients with hepatic impairment.
Patients with Renal Impairment: In patients with creatinine clearance less than or equal to 60 mL/min, the dose of Cefepime should be adjusted to compensate for the slower rate of renal elimination. The recommended initial dose of Cefepime should be the same as in patients with normal renal function except in patients undergoing hemodialysis.
The recommended doses of Cefepime in patients with renal impairment are presented in Table 5. When only serum creatinine is available, the following formula (Cockcroft and Gault equation) may be used to estimate creatinine clearance. The serum creatinine should represent a steady state of renal function. (See Table 5.)

Click on icon to see table/diagram/image

In patients undergoing continuous ambulatory peritoneal dialysis, Cefepime may be administered at normally recommended doses at a dosage interval of every 48 hours.
In patients undergoing hemodialysis, approximately 68% of the total amount of cefepime present in the body at the start of dialysis will be removed during a 3-hour dialysis period. The dosage of Cefepime for hemodialysis patients is 1 g on Day 1 followed by 500 mg every 24 hours for the treatment of all infections except febrile neutropenia, which is 1 g every 24 hours.
Cefepime should be administered at the same time each day and following the completion of hemodialysis on hemodialysis days.
Data in pediatric patients with impaired renal function are not available; however, since cefepime pharmacokinetics are similar in adults and pediatric, changes in the dosing regimen proportional to those in adults are recommended for pediatric patients.
Direction for Reconstitution: Dissolve the contents in 10 mL (for intravenous administration) and 2.4 mL (for intramuscular injection) of Sterile Water for Injection or in 0.9% Sodium Chloride or in 5% Dextrose Injection.