Medicol Advance/Medicol Advance 400 Drug Interactions

Blood concentrations of ibuprofen may be decreased when given together with aspirin.
Phenylbutazone, indomethacin, salicylates, and other NSAIDs (e.g., mefenamic acid, naproxen, diclofenac, ketoprofen) increase the risk of stomach and intestinal bleeding in patients receiving ibuprofen.
When taken with blood thinning (anticoagulant) medicines (e.g., warfarin, dicumarol) or together with thrombolytic agents (e.g., streptokinase), ibuprofen may cause stomach and intestinal bleeding.
Corticosteroids (e.g., prednisone, prednisolone), selective serotonin reuptake inhibitors (SSRIs) [e.g., citalopram, escitalopram, sertraline] may increase the risk of stomach bleeding with ibuprofen.
Ibuprofen may cause acute reduction in kidney function and blood pressure response to ACE inhibitors (e.g., captopril, enalapril, ramipril, imidapril, fosinopril, lisinopril).
Ibuprofen should not be used 8-12 days after mifepristone use because it can reduce the effect of mifepristone.
Ibuprofen may reduce the effect of diuretics such as furosemide and thiazide.
Ibuprofen reduces methotrexate excretion from the body, thus increasing the risk of methotrexate toxicity.
Ibuprofen increases the amount of lithium in the blood (increased risk of lithium toxicity) probably by reducing excretion of lithium.
Ibuprofen may increase the plasma concentration of cardiac glycosides (e.g., digitalis), worsen cardiac failure and reduce renal function.
Ibuprofen may enhance the effect of phenytoin, an antiepileptic medicine.
There is an increased risk of nephrotoxicity (kidney damage) when ciclosporin or tacrolimus are given together with ibuprofen.
Ginkgo biloba may enhance the risk of bleeding when given with ibuprofen.
Medicol Advance 400: An increased risk of blood problems such as bleeding into a joint (hemarthrosis) and bruising (hematoma) may result when ibuprofen is given with antiviral medicines such as zidovudine.
A possible increased risk of convulsions may occur when ibuprofen is taken with quinolones (e.g., ofloxacin, levofloxacin, norfloxacin, ciprofloxacin, sparfloxacin, moxifloxacin).