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Metronidazole should be used with great care in patients with blood dyscrasias or with active disease of the central nervous system. All patients receiving Metronidazole for more than 10 days should be monitored and treatment discontinued if signs of peripheral neuropathy or CNS toxicity develop. Doses should be reduced in patients with severe liver disease.
It is suggested that the use of Metronidazole should be avoided during pregnancy, especially the first trimester and especially high-dose regimens. Some authorities consider that women taking Metronidazole should not breast-feed their babies.
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