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Pharmacologic Classification: Non-Steroidal Anti-Inflammatory.
Pharmacology: Pharmacokinetics: Absorption: Absorbed from the gastrointestinal tract, partially into the skin, and almost completely absorbed after rectal administration. Food intake decreases absorption rate. Time to peak plasma concentration: 1-2 hours (oral); 0.75 hours (rectal).
Distribution: Enters breast milk. Plasma protein binding: 90-99%.
Metabolism: Metabolised in the liver via oxidation.
Excretion: Mainly via urine (45-80% as metabolites, approx 1% as unchanged drug); faeces. Elimination half-life: Approx 2 hours.
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