Medaxone Caution For Usage

Instruction and Special Precautions for Handling disposal: Concentrations for the intravenous injection: 100 mg/mL, Concentrations for the intravenous infusion: 50 mg/mL.
Reconstitution for injection: Reconstitution should be carried out under suitable conditions and with appropriate precautions to prevent microbial contamination. It is recommended that freshly prepared solutions be used; the solutions retain satisfactory potency for six hours at a temperature not exceeding 25°C, and up to twenty four hours at 2 to 8°C. Following reconstitution, a pale yellow to amber solution is produced.
Intramuscular injection: Reconstitution uses Lignocaine hydrochloride 1.06% injection; 1 g should be reconstituted using 3.5 mL of lignocaine hydrochloride 1.06% injection. Administration is by deep intramuscular injection. If the dosage exceeds 1 g, the dose should be divided equally and administered at more than one injection site. Solutions reconstituted in lignocaine should not be administered intravenously.
Intravenous injection: Reconstitution uses Water for Injection; 1 g should be dissolved in 10 mL of water. Administration is by slow intravenous injection over two to four minutes.
Intravenous infusion: 2 g of ceftriaxone should be dissolved in 40 mL of one of the following calcium-free solutions; Glucose Intravenous Infusion 5% or 10%, Sodium Chloride Intravenous Infusion, Sodium Chloride and Glucose Intravenous Infusion (0.45% sodium chloride and 2.5% Glucose), Dextran 6% in Glucose Injection 5%, isotonic hydroxyethylstarch 6-10% infusions. The infusion should be administered over at least 30 minutes.
Diluents containing calcium (e.g. Ringer's solution or Hartmann's solution), should not be used to reconstitute ceftriaxone vials or to further dilute a reconstituted vial for IV administration because a precipitate can form. Precipitation of ceftriaxone-calcium can also occur when ceftriaxone is mixed with calcium-containing solutions in the same IV administration line. Therefore, ceftriaxone and calcium-containing solutions must not be mixed or administered simultaneously.
Reconstitution should be carried out under suitable aseptic precautions. Following reconstitution the solution should be visually examined for any foreign particulate matter and discarded if any is observed. It is recommended that reconstituted solution is used immediately following preparation. The solutions retain satisfactory potency for six hours at a temperature not exceeding 25°C, and up to twenty four hours at 2 to 8°C. Medaxone vials are for single use only, any remaining suspension/solution should be discarded.