M-Vac Description

M-Vac (Live Attenuated Measles Vaccine (Freeze-dried) Powder for Injection, S.C.) is prepared from the Edmonston strain measles virus which has been further attenuated by twenty two passages on human diploid cells (HDC) and is known as the Edmonston-Zagreb strain. The virus in the final vaccine is also propagated on HDC and is from the second cell culture passage from the seed virus. The vaccine is lyophilized and is provided with diluent. The product has the appearance of a yellowish-white dry cake. The vaccine meets the requirements of W.H.O. when tested by the methods outlined in W.H.O., TRS 840 (1994).
Potency: Each single human dose when reconstituted in a volume of 0.5 mL contains not less than 1000 CCID₅₀ of live virus particles. Stability data has shown that the freeze-dried vaccine retains the potency of 1000 CCID₅₀ per dose after 1 week at 37°C.