Known hypersensitivity to lurasidone HCl or any components in the formulation. Angioedema has been observed with lurasidone; Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin, ritonavir, voriconazole, mibefradil, etc.); Strong CYP3A4 inducers (e.g., rifampin, avasimibe, St. John's wort, phenytoin, carbamazepine, etc). Grapefruit and grapefruit juice should be avoided in patients taking lurasidone hydrochloride tablets, since they may inhibit CYP3A4 and alter lurasidone hydrochloride tablets concentrations.