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This combination is not suitable for the treatment of diabetes mellitus type 1 (e.g. for the treatment of diabetics with a history of ketoacidosis), or of diabetic precoma or coma.
It must not be used in patients hypersensitive to metformin hydrochloride, glimepiride, sulfonylureas, other sulfonamides, or any of the excipients (risk of hypersensitivity reactions).
Impaired renal function; acute complications (severe infections, major operations and trauma); before x-ray examinations with iodinated contrast materials; liver damage; alcoholism; deficiencies of vitamin B12, folic acid and iron; ketosis-prone diabetes; severe cardiovascular or respiratory disease; general ill health (malnutrition, dehydration, etc); diabetes with significant late complications (nephropathy, retinopathy).
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