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Silibinin: Silibinin has generally been well tolerated in recommended doses for up to 6 years. At high doses, a laxative effect may occur.
Phosphatidylcholine: There is no reported acute or chronic toxicity from phosphatidylcholine. Daily intakes of up to 18 grams have been generally well tolerated.
Nicotinic Acid: In normal doses, nicotinic acid is not toxic, but chronic administration at doses of 3 g daily for periods greater than three months may cause adverse effects (see Adverse Reactions).
Zinc: Signs of acute zinc toxicity (doses > 200 mg daily) include GI pain/cramps, nausea, vomiting, diarrhea, loss of appetite, headache, lethargy, muscle pain, and fever.
Chronic zinc toxicity may cause impairment of copper and iron status, anemia, and immune deficiency. Some findings have linked chronic zinc toxicity to the development of atherosclerosis because of a lowering of blood HDL levels.
If taken more than the recommended dosage, consult a doctor.
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