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Lithium should not be given during pregnancy and without careful weighing of risk versus benefit. Lithium should be used during pregnancy only in severe disease for which safer drugs cannot be used or are ineffective. When possible, lithium should be withdrawn for at least the first trimester unless it is determined that this would seriously endanger the mother. Serum lithium concentrations should be carefully monitored and dosage adjusted if necessary since renal clearance of the drug and distribution of the drug erythrocytes may be increased during pregnancy.
Lithium passes into milk and its use should be avoided during lactation.
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