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Discontinuation: In accordance with current clinical practice, if levetiracetam has to be discontinued, it is recommended to withdraw it gradually (e.g. in adults and adolescents weighing more than 50 kg: 500 mg decreases twice daily every two or four weeks; In children and adolescents weighing less than 50 kg: dose decreases should not exceed 10 mg/kg twice daily every two weeks).
Renal or hepatic impairment: The administration of levetiracetam to patients with renal impairment may require dose adjustment. In patients with severely impaired hepatic function, assessment of renal function is recommended before dose selection.
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