Levecortix-100/Levecortix-250 Adverse Reactions

Levecortix-100: Since Hydrocortisone sodium succinate for injection is normally employed on a short term basis it is unlikely that side-effects will occur; however, the possibility of side effects attributable to corticosteroid therapy should be recognised.
Such side effects include: Parenteral corticosteroid therapy: Anaphylactoid reaction, e.g. Bronchospasm, hypopigmentation or hyper-pigmentation, subcutaneous and cutaneous atrophy, sterile abscess, laryngeal oedema and uticaria.
Gastrointestinal: Dyspepsia, peptic ulcer with perforation and haemorrhage, abdominal distension, eosophageal ulceration, oesophageal candidiasis, acute pancreatitis, perforation of bowel, increase in alanine transaminase (ALT, SGPT) aspartate transaminase (AST, SGOT) and alkaline phosphatase have been observed following corticosteroid treatment.
Anti-inflammatory and lmmunosuppressive effects: Increased susceptibility and severity of infections with suppression of clinical symptoms and sign, opportunistic infections, may suppress reactions to skin tests, recurrence of dormant tuberculosis.
Musculoskeletal: Proximal myopathy, osteoporosis, vertebral and long bone fractures, avascular osteonecrosis, tendon rupture, aseptic necrosis, muscle weakness.
Levecortix-250: Since hydrocortisone is normally employed on a short-term basis it is unlikely that side effects will occur; however, the possibility of side effects attributable to corticosteroid therapy should be recognised. Such side effects include: See Table 1.

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