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Pharmacology: Pharmacodynamics: Levodropropizine, the S-isomer of dropropizine, has a predominant peripheral antitussive action which acts by inhibiting the sensory C-fiber activation and the release of neuropeptides. It is a cough sedative with bronchial muscle relaxant action, thus improving pulmonary ventilation. However, it is exempted from secondary reactions of central antitussive action.
Pharmacokinetics: Levodropropizine is rapidly absorbed after oral administration and peak plasma concentration occurred within 40 minutes. The bioavailability of levodropropizine is more than 75%.
Levodropropizine is 11 to 14% bound to plasma proteins.
It is unknown whether levodropropizine is metabolized in the liver.
The plasma elimination half-life of levodropropizine is 1 to 2 hours. Approximately 35% of levodropropizine is excreted unchanged in the urine within 48 hours.
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