Sign Out
Valproic acid should not be administered to patients with hepatic disease or significant hepatic dysfunction (see Hepatotoxicity under Precautions).
Valproic acid is contraindicated in patients known to have mitochondrial disorders caused by mutations in mitochondrial DNA polymerase γ (POLG; eg, Alpers-Huttenlocher syndrome) and children under to years of age who are suspected of having a POLG-related disorder (see Hepatoxicity under Precautions).
Valproic acid is contraindicated in patients with known hypersensitivity to the drug (see Multiorgan hypersensitivity under Precautions).
Valproic acid is contraindicated in patients with known urea cycle disorders (see Urea cycle disorders under Precautions).
Valproic acid is contraindicated in patients with porphyria.
Valproic acid is contraindicated for use in prophylaxis of migraine headaches in pregnant women (see Use in Pregnancy & Lactation).
Continue with Google