Leponex Indications/Uses

Treatment-resistant schizophrenia: Clozapine (Leponex) is indicated in patients with treatment-resistant schizophrenia, i.e. patients with schizophrenia who are non-responsive to or intolerant of classic antipsychotics.
Non-responsiveness is defined as a lack of satisfactory clinical improvement despite the use of adequate doses of at least two marketed antipsychotics prescribed for adequate durations.
Intolerance is defined as the impossibility of achieving adequate clinical benefit with classic antipsychotics because of severe and untreatable neurological adverse reactions (extrapyramidal side effects or tardive dyskinesia).
Risk of recurrent suicidal behavior: Clozapine (Leponex) is indicated for reducing the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder who are judged to be at chronic risk for re-experiencing suicidal behavior, based on history and recent clinical state. Suicidal behavior refers to actions by a patient that put him/herself at high risk for death.
Psychosis during the course of Parkinson's disease: Clozapine (Leponex) is indicated in psychotic disorders occurring during the course of Parkinson's disease, in cases where standard treatment has failed.
The failure of standard treatment is defined as the lack of control of the psychotic symptoms and/or the onset of functionally unacceptable motoric deterioration occurring after the following measures have been taken: Withdrawal of anticholinergic medication including tricyclic antidepressants; Attempt to reduce the dose of antiparkinsonian medication with dopaminergic effect.