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Use in Pregnancy: Pregnancy Category C. It has been reported from individual cases that levodopa crosses the human placental barrier, enters the fetus, and is metabolized. Carbidopa concentrations in fetal tissue appeared to be minimal. Levodopa + carbidopa should be administered to pregnant women or women who might become pregnant only when the benefits to the mother outweigh the possible risks to the mother and fetus since there are no adequate or well-controlled studies available.
Use in Lactation: Caution should be exercised since excretion of levodopa in human breast milk was reported in a study of one breastfeeding mother with Parkinson's disease and levodopa inhibits prolactin excretion, interfering with breastfeeding.
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