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Lactitol can increase the potassium losses caused by other medicines (e.g. thiazide diuretics, corticosteroids, carbenoxolone, amphotericin B). Potassium deficiency may increase the risk of toxic effects of glycosides in patients receiving concomitant
therapy.
Lactitol can also increase digitalis toxicity. Concomitant administration of lactitol with neomycin can cause an increase in neomycin activity.
If large spectrum antibacterial agents are administered along with lactitol it can cause a reduction in acidication effect on intestinal microflora and consequently limiting therapeutic efficacy.
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