Kytril Dosage/Direction for Use

Standard dosage by formulation and indication for adult and pediatric patients are shown as follows.
Indication: Chemotherapy Induced Nausea and Vomiting (CINV): Adults: Prevention: A dose of 1-3 mg (10-40 mcg/kg) of Kytril should be administered either as a slow intravenous injection (over 30 seconds) or as an intravenous infusion diluted in 20 to 50 ml infusion fluid and administered over 5 minutes, prior to the start of chemotherapy.
Treatment: A dose of 1-3 mg (10-40 mcg/kg) Kytril should be administered either as a slow intravenous injection (over 30 seconds) or as an intravenous infusion diluted in 20 to 50 ml infusion fluid and administered over 5 minutes. Further treatment doses of Kytril may be administered, if required, at least 10 minutes apart. The maximum dose of Kytril to be administered over 24 hours should not exceed 9 mg.
Pediatrics: Prevention and treatment: A dose of 10-40 mcg/kg body weight (up to 3 mg) should be administered as an intravenous infusion, diluted in 10 to 30 ml over 5 minutes prior to the start of chemotherapy. One additional dose may be administered within a 24-hour period if required. This additional dose should not be administered until at least 10 minutes after the initial infusion.
Indication: Radiotherapy Induced Nausea and Vomiting (RINV): Adults: Prevention: A dose of 1-3 mg (10-40 mcg/kg) of Kytril should be administered either as a slow intravenous injection (over 30 seconds) or as an intravenous infusion diluted in 20 to 50 ml infusion fluid and administered over 5 minutes, prior to the start of radiotherapy.
Treatment: There is insufficient information to recommend the intravenous administration of Kytril in the treatment of RINV in adult patients.
Pediatrics: There is insufficient information to recommend intravenous administration of Kytril in the prevention and treatment of RINV in pediatric patients.
Indication: Post-operative Nausea and Vomiting (PONV): Adults: Prevention: A dose of 1 mg (10 mcg/kg) of Kytril should be administered as a slow intravenous injection (over 30 seconds) prior to induction of anesthesia.
Treatment: A dose of 1 mg (10 mcg/kg) of Kytril should be administered by slow intravenous injection (over 30 seconds). The maximum dose for patients undergoing anesthesia for surgery is a total dose of 3 mg of Kytril i.v. in one day.
Pediatrics: There is insufficient information to recommend the intravenous administration of Kytril in the prevention and treatment of PONV in pediatric patients.
Special Dosage Instructions: Geriatrics: No dosage adjustments required.
Renal impairment: No dosage adjustments required.
Hepatic impairment: No dosage adjustments required.