Kremezin Mechanism of Action

Pharmacology: Pharmacodynamics: Mechanism of Action: When this product is administered orally to patients with chronic renal failure, it improves uremic symptoms and prolongs the time to initiation of dialysis, since the uremic toxins are adsorbed by this product in the digestive tract and excreted with the feces.
When this product is administered to model rats with renal failure, it exerted the inhibitory effect on aggravation of renal failure (maintenance of food consumption and body weight, inhibitory effect on increase of serum creatinine and blood urea nitrogen, inhibitory effect on decreasing glomerular filtration function and inhibition on aggravation of renal tissue lesion) and the number of the surviving days is prolonged.
When this product is administered orally to patients with chronic renal failure in the conservative therapy, it inhibits the increase of serum creatinine, improves uremic symptoms and prolongs the time to the initiation of dialysis.
Pharmacokinetics: When ¹⁴C-labeled SPH ERICAL CARBON ADSORBENT (Kremezin) was administered orally to mice, it was excreted with the feces almost completely within 24 hours after administration and no in vivo absorption or accumulation of this product were noted.