Krabinex Adverse Reactions

Dermatological Problems: Alopecia occurs very rarely. Occasionally, maculopapular rash and facial erythema may occur. Hydroxyurea may exacerbate the erythema caused by irradiation therapy.
Gastrointestinal Disturbances: Stomatitis, inappetence, nausea, vomiting, diarrhea and constipation may occur.
Hematological Problems: Primarily, bone marrow depression (leukopenia, anemia, thrombocytopenia) may occur.
Megaloblastic erythropoiesis, which is self-limiting, is often seen in the early course of Hydroxyurea therapy.
Hepatic Abnormalities: Abnormal BSP retention and elevation of hepatic enzymes have been reported.
Neurotoxicity: At a higher dose, a general lethargic state may occur and flush, chill and malaise have been reported.
Psychoneural Disturbances: Rarely, headache, dizziness, drowsiness, disorientation, hallucinations and convulsions may occur.
Renal Problems: Dysuria occurs very rarely. Hydroxyurea occasionally, may cause temporary impairment of renal tubular function accompanied by elevations in serum uric acid, BUN and creatinine levels.
Others: Edema has been reported to occur.