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Clinical features of clarithromycin overdosage may include GI symptoms such as abdominal pain, nausea, vomiting, and diarrhea. One patient who had a history of bipolar disorder ingested 8 g of clarithromycin and showed altered mental status, paranoid behavior, hypokalemia and hypoxemia.
Adverse reactions accompanying overdosage should be treated promptly by elimination of unabsorbed drug and supportive measures. As with other macrolides, clarithromycin serum concentrations are not expected to be appreciably removed by hemodialysis or peritoneal dialysis.
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