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Hypersensitivity: angioedema.
Hydrochlorothiazide therapy is associated with electrolyte imbalance: namely, hyponatremia, hypochloremic alkalosis and hypokalemia. Periodic determination of serum electrolytes to detect possible electrolyte imbalance should be performed at appropriate intervals.
Hyperglycemia may occur with thiazide diuretics. In diabetic patients, dosage adjustments of insulin or oral hypoglycemic agents may be required.
Impaired renal function.
Symptomatic hypotension.
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