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Concomitant administration of potassium salts and potassium-sparing diuretics like aldosterone antagonists (e.g. spironolactone), amiloride or triamterene may cause severe hyperkalemia and should be avoided.
Tacrolimus may cause hyperkalemia or increase the serum concentration of potassium which should be taken into account when combined with potassium salts.
ACE inhibitors may produce some increase in potassium serum levels by inhibiting aldosterone secretion. Potassium supplements should be given to patients concomitantly taking ACE inhibitors only with close monitoring of potassium levels.
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