Itrazole Contraindications

Itraconazole Capsules are contraindicated in patients with known hypersensitivity to Itraconazole or to any of the excipients.
Co-administration of a number of CYP3A4 substrates is contraindicated with Itraconazole Capsules. Increased plasma concentrations of these drugs, caused by co-administration with Itraconazole, may increase or prolong both therapeutic and adverse effects to such an extent that a potentially serious situation may occur. For example, increased plasma concentrations of some of these drugs can lead to QT prolongation and ventricular tachyarrhythmias including occurrences of torsade de pointes, a potentially fatal arrhythmia.
Itraconazole Capsules should not be administered to patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF except for the treatment of life-threatening or other serious infections.
Itraconazole Capsules must not be used during pregnancy except for life-threatening cases. Women of childbearing potential taking Itraconazole Capsules should use contraceptive precautions. Effective contraception should be continued until the menstrual period following the end of Itraconazole Capsules therapy.