Iroferose Caution For Usage

For single use only.
Intravenous Drip Infusion: Iron sucrose Injection USP must be diluted only in sterile 0.9% w/v sodium chloride solution: 5 mL Iron sucrose Injection USP (100 mg iron).
In max. 100 mL sterile 0.9% w/v sodium chloride solution.
10 mL Iron sucrose Injection USP (200 mg iron).
In max. 200 mL sterile 0.9% w/v sodium chloride solution.
For stability reasons, dilutions to lower Iron sucrose Injection USP concentrations are not permissible.
Dilution must take place immediately prior to infusion and the solution should be administered as follows: 100 mg iron (5 mL Iron sucrose Injection USP) in at least 15 minutes; 200 mg iron (10 mL Iron sucrose Injection USP) in at least 30 minutes.
The first 25 mg of iron (i.e. 25 mL of solution) should be infused as a test dose over a period of 15 minutes. If no adverse reactions occur during this time then the remaining portion of the infusion should be given at an infusion rate of not more than 50 mL in 15 minutes.
Intravenous Injection: Iron sucrose Injection USP may be administered by slow intravenous injection at a rate of 1 mL undiluted solution per minute (i.e. 5 minutes per ampoule) and not exceeding 2 ampoules Iron sucrose Injection USP (200 mg iron) per injection.
Before administering a slow intravenous injection, a test dose of 1 mL (20 mg of iron) should be injected slowly over a period of 1 to 2 minutes. If no adverse events occur within 15 minutes of completing the test dose, then the remaining portion of the injection may be given.
Injection into Dialyser: Iron sucrose Injection USP may be administered during a hemodialysis session directly into the venous limb of the dialyser under the same procedures as those outlined for intravenous injection.