Invega Sustenna Caution For Usage

Incompatibilities: Paliperidone palmitate (Invega Sustenna) should not be mixed with any other product or diluent and is intended for intramuscular administration directly from the syringe in which it is packaged.
Instructions For Use and Handling and Disposal: The kit contains a prefilled syringe and 2 safety needles (a 1½-inch 22 gauge needle and a 1-inch 23 gauge needle) for intramuscular injection.
Paliperidone palmitate (Invega Sustenna) is for single use only.
1. Shake the syringe vigorously for a minimum of 10 seconds to ensure a homogeneous suspension.
2. Select the appropriate needle.
For DELTOID injection, if the patient weighs <200 lb (<90 kg), use the 1-inch 23 gauge needle (needle with blue colored hub); if the patient weighs ≥200 lb (≥90 kg), use the 1½-inch 22 gauge needle (needle with gray colored hub).
For GLUTEAL injection, use the 1½-inch 22 gauge needle (needle with gray colored hub).
3. Hold the syringe with the tip cap pointing up, remove the rubber tip cap with a gentle twisting motion.
4. Peel the safety needle pouch half way open. Grasp the needle sheath using the plastic peel pouch. Hold the syringe pointing up. Attach the safety needle to the syringe using a gentle twisting motion to avoid needle hub cracks or damage. Always check for signs of damage or leaking prior to administration.
5. Pull the needle sheath away from the needle with a straight pull. Do not twist the sheath as the needle may be loosened from the syringe.
6. Bring the syringe with the attached needle in upright position to de-aerate. De-aerate the syringe by moving the plunger rod carefully forward.
7. Inject the entire contents intramuscularly slowly, deep into the selected deltoid or gluteal muscle of the patient. Do not administer intravascularly or subcutaneously.
8. After the injection is complete, use either thumb or finger of one hand or a flat surface to activate the needle protection system. The needle protection system is fully activated when a 'click' is heard. Discard the syringe with needle appropriately.