Infekor Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Cefuroxime Na

Indications/Uses

Community acquired pneumonia; acute exacerbations of chronic bronchitis; complicated UTI, including pyelonephritis; cellulitis, erysipelas & wound infections; intra-abdominal infections; prophylaxis against infection in GI (including oesophageal), orthopaedic, CV, & gynaecological surgery (including caesarean section).

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Dosage/Direction for Use

Adult & childn ≥40 kg Community acquired pneumonia & acute exacerbations of chronic; cellulitis, erysipelas & wound infections; intra-abdominal infections 750 mg every 8 hr (IV or IM). Complicated UTI, including pyelonephritis 1.5 g every 8 hr (IV or IM). Severe infections 750 mg every 6 hr (IV) or 1.5 g every 8 hr (IV). Surgical prophylaxis for GI, gynecological surgery (including caesarean section) & orthopaedic operations 1.5 g w/ induction of anaesth. May be supplemented w/ two 750 mg doses (IM) after 8 hr & 16 hr. Surgical prophylaxis for CV & oesophageal operations 1.5 g w/ induction of anaesth followed by 750 mg (IM) every 8 hr for a further 24 hr. Community acquired pneumonia & acute exacerbations of chronic; cellulitis, erysipelas & wound infections; intra-abdominal infections Childn <40 kg, infants & toddlers >3 wk 30-100 mg/kg/day (IV) in 3 or 4 divided doses. 60 mg/kg/day is appropriate for most infections. Infants (birth to 3 wk) 30-100 mg/kg/day (IV) in 2 or 3 divided doses. CrCl >20 mL/min/1.73 m² 750 mg to 1.5 g tid. CrCl 10-20 mL/min/1.73 m² & <10 mL/min/1.73 m² 750 mg bid. Patient on haemodialysis Further 750 mg dose should be given IV or IM at the end of each dialysis. Patient in renal failure on continuous arteriovenous haemodialysis (CAVH) or high-flux haemofiltration (HF) in intensive therapy units 750 mg bid.

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Overdosage

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Contraindications

Hypersensitivity to cefuroxime, cephalosporin antibiotics. History of severe hypersensitivity (eg, anaphylactic reaction) to other type of β-lactam antibacterial agent (penicillins, monobactams & carbapenems).

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Special Precautions

History of severe hypersensitivity reactions to cefuroxime, other cephalosporins or any other type of β-lactam agent. Caution to patients receiving potent diuretics (eg, furosemide) or aminoglycosides. Monitor renal function in elderly & those w/ known pre-existing renal impairment. Avoid prolonged treatment. Not suitable for infections caused by gram -ve non-fermenting bacteria. May interfere w/ a +ve Coombs test. Slight interference w/ Cu reduction methods (Benedict's, Fehling's, clinitest). False -ve result may occur in the ferricyanide test. Not formulated for intracameral use. Reports of individual cases & clusters of serious ocular adverse reactions. Na intake should be considered for patients on a controlled Na diet. Pregnancy & lactation.

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Use In Pregnancy & Lactation

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Adverse Reactions

Neutropenia, eosinophilia, decreased Hb conc; transient rise in liver enzymes; skin rash, urticaria & pruritus; inj site reactions which may include pain & thrombophlebitis.

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Drug Interactions

May affect the gut flora, leading to lower oestrogen reabsorption & reduced efficacy of combined OCs. Prolongs the excretion of cefuroxime & produces an elevated peak serum level of probenecid. Concomitant administration of strong-acting diuretics (eg, furosemide) or potential nephrotoxic prep (eg, aminoglycoside antibiotics). May increase INR of oral anticoagulants.

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Caution For Usage

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Storage

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Description

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Action

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MIMS Class

Cephalosporins

ATC Classification

J01DC02 - cefuroxime ; Belongs to the class of second-generation cephalosporins. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Infekor powd for inj 750 mg

Packing/Price

1's

Infekor

cefuroxime

Manufacturer:

Swiss Parenterals Ltd

Distributor:

One Pharma