Immunorel Special Precautions

Prior to initiation of immunoglobulin therapy, it is essential to correct volume depletion of the patient by infusing appropriate fluids. Periodic monitoring of renal function tests and urine output is particularly important in patients judged to have a potential increased risk for developing acute renal failure. Renal function, including measurement of blood urea nitrogen (BUN), serum creatinine, should be assessed prior to the initial infusion of immunoglobulin and again at appropriate intervals thereafter. If renal function deteriorates, discontinuation of the product should be considered.
It is generally advisable not to dilute plasma derivatives with other infusible drugs. Immunoglobulin Normal, Human (ImmunoRel) should be given by a separate infusion line. No other medications or fluids should be mixed with the Immunoglobulin Normal, Human (ImmunoRel) preparation.
Use in Pregnancy & Lactation: Pregnancy Category C: Animal reproduction studies have not been conducted with Immunoglobulin Normal, Human (ImmunoRel). It is also not known whether Immunoglobulin Normal, Human (ImmunoRel) can cause foetal harm when administered to a pregnant woman or can affect reproduction capacity. This preparation should be given to a pregnant woman only if clearly needed.
Intact immune globulins such as those contained in Immunoglobulin Normal, Human (ImmunoRel) cross the placenta from maternal circulation increasingly after 30 weeks gestation. In cases of maternal ITP where IVIG was administered to the mother prior to delivery, the platelet response and clinical effect were similar in the mother and neonate.
Use in Children & Elderly: High dose administration of IVIG in paediatric patients with acute or chronic Immune Thrombocytopenic Purpura has not revealed any paediatric specific hazard.
Antibodies in IVIG, may impair the efficacy of live attenuated viral vaccines such as measles, rubella, and mumps. Immunizing physicians should be informed of recent therapy with IVIG so that appropriate precautions may be taken.