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Hypersensitivity to the active substance or to any of the excipients of this formulation.
Known hypersensitivity to sulphonamides.
Active peptic ulceration or gastrointestinal (GI) bleeding.
Patients who have experienced asthma, acute rhinitis, nasal polyps, angioneurotic oedema, urticaria or other allergic-type reactions after taking acetylsalicylic acid (aspirin) or other NSAIDs including COX-2 inhibitors.
Breast-feeding.
Severe hepatic dysfunction (serum albumin <25 g/L or Child-Pugh score=10).
Patients with estimated creatinine clearance <30 mL/min.
Inflammatory bowel disease.
Congestive heart failure, (NYHA II-IV).
Established ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease.
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