Hyzaar/Hyzaar DS Dosage/Direction for Use

LOSARTAN POTASSIUM + HYDROCHLOROTHIAZIDE (HYZAAR) may be administered with other antihypertensive agents.
LOSARTAN POTASSIUM + HYDROCHLOROTHIAZIDE (HYZAAR) may be administered with or without food.
Hypertension: The usual starting and maintenance dose of LOSARTAN POTASSIUM + HYDROCHLOROTHIAZIDE (HYZAAR) is one tablet of LOSARTAN POTASSIUM 50 mg + HYDROCHLOROTHIAZIDE 12.5 mg (HYZAAR) once daily. For patients who do not respond adequately to LOSARTAN POTASSIUM 50 mg + HYDROCHLOROTHIAZIDE 12.5 mg (HYZAAR), the dosage may be increased to one tablet of LOSARTAN POTASSIUM 100 mg + HYDROCHLOROTHIAZIDE 25 mg (HYZAAR DS) once daily or two tablets of LOSARTAN POTASSIUM 50 mg + HYDROCHLOROTHIAZIDE 12.5 mg (HYZAAR) once daily. The maximum dose is one tablet of LOSARTAN POTASSIUM 100 mg + HYDROCHLOROTHIAZIDE 25 mg (HYZAAR DS) once daily or two tablets of LOSARTAN POTASSIUM 50 mg + HYDROCHLOROTHIAZIDE 12.5 mg (HYZAAR) once daily. In general, the antihypertensive effect is attained within three weeks after initiation of therapy. LOSARTAN POTASSIUM + HYDROCHLOROTHIAZIDE (HYZAAR) 100/12.5 is available for those patients titrated to 100 mg of LOSARTAN POTASSIUM (COZAAR) who require additional blood pressure control.
LOSARTAN POTASSIUM + HYDROCHLOROTHIAZIDE (HYZAAR) should not be initiated in patients who are intravascularly volume-depleted (e.g., those treated with high-dose diuretics).
LOSARTAN POTASSIUM + HYDROCHLOROTHIAZIDE (HYZAAR) is not recommended for patients with severe renal impairment (creatinine clearance ≤30 mL/min) or for patients with hepatic impairment.
No initial dosage adjustment of LOSARTAN POTASSIUM + HYDROCHLOROTHIAZIDE (HYZAAR) 50-12.5 is necessary for elderly patients. LOSARTAN POTASSIUM + HYDROCHLOROTHIAZIDE (HYZAAR DS) 100-25 should not be used as initial therapy in elderly patients.
Reduction in the Risk of Cardiovascular Morbidity and Mortality in Hypertensive Patients with Left Ventricular Hypertrophy: The usual starting dose is 50 mg of losartan once daily. If goal blood pressure is not reached with losartan 50 mg, therapy should be titrated using a combination of losartan and a low dose of hydrochlorothiazide (12.5 mg) and, if needed, the dose should then be increased to losartan 100 mg and hydrochlorothiazide 12.5 mg once daily. If necessary, the dose should be increased to losartan 100 mg and hydrochlorothiazide 25 mg once daily. LOSARTAN POTASSIUM + HYDROCHLOROTHIAZIDE (HYZAAR) 50/12.5, LOSARTAN POTASSIUM + HYDROCHLOROTHIAZIDE (HYZAAR) 100/12.5 and LOSARTAN POTASSIUM + HYDROCHLOROTHIAZIDE (HYZAAR DS) 100/25 are suitable alternative formulations in patients who would otherwise be treated concomitantly with losartan plus hydrochlorothiazide.