Humalog Mix50 KwikPen Caution For Usage

Incompatibilities: Mixing 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) with other insulins has not been studied. In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products.
Special precautions for disposal and other handling: To prevent the possible transmission of disease, each pen must be used by one patient only, even if the needle is changed. The patient should discard the needle after every injection.
The Insulin Lispro (Humalog Mix50 KwikPen) should be examined frequently and should not be used if clumps of material are present or if solid white particles stick to the bottom or wall of the cartridge, giving a frosted appearance.
Preparing a dose: The KwikPen containing Insulin Lispro (Humalog Mix50 KwikPen) should be rotated in the palms of the hands ten times and inverted 180° ten times immediately before use to resuspend the insulin until it appears uniformly cloudy or milky. If not, repeat the previously mentioned procedure until contents are mixed. Cartridges contain a small glass bead to assist mixing.
Do not shake vigorously as this may cause frothing which may interfere with the correct measurement of dose.
Before using the KwikPen the user manual included in the package leaflet must be read carefully. The KwikPen has to be used as recommended in the user manual.
Pens should not be used if any part looks broken or damaged.
Injecting a dose: If using a pre-filled pen refer to the detailed instructions for preparing the pen and injecting the dose, the following is a general description.
1. Wash the hands.
2. Choose a site for injection.
3. Clean the skin as instructed.
4. Stabilize the skin by spreading it or pinching up a large area. Insert the needle and inject as instructed.
5. Pull the needle out and apply gentle pressure over the injection site for several seconds. Do not rub the area.
6. Using the outer needle cap, unscrew the needle and dispose of it safely.
7. Use of injection sites should be rotated so that the same site is not used more than approximately once a month.
Any unused product or waste material should be disposed of in accordance with local requirements.