Hi-Perazone Caution For Usage

Reconstitution: See Table 2.

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Cefoperazone + Sulbactam has been shown to be compatible with these diluents: Water for injection, 5% dextrose in 0.225% saline, and 5% dextrose in normal saline. Cefoperazone is compatible at concentrations ranging from 10 to 250 mg/mL of diluent. Sulbactam is compatible at concentrations ranging from 5 to 125 mg/ml of diluent.
Lactated Ringer's Solution: Sterile Water for Injection should be used for reconstitution. A two-step dilution is required using Sterile Water for Injection (shown in Table 2) further diluted with Lactated Ringer's Solution to a Sulbactam concentration of 5 mg/mL (use 2 mL initial dilution in 50 mL or 4 mL initial dilution in 100 mL Lactated Ringer's Solution).
Lidocaine: Sterile Water for Injection should be used for reconstitution. For a concentration of Cefoperazone of 250 mg/mL or larger, a two-step dilution is required using Sterile Water for Injection (shown in Table 2) further diluted with 2% lidocaine to yield solutions containing up to 250 mg.
Cefoperazone and 125 mg Sulbactam per mL in approximately a 0.5% lidocaine HCl solution.
Intramuscular Administration: Lidocaine Injection BP 2% is a suitable vehicle for intramuscular administration; however, it is not for initial reconstitution.
Lidocaine HCI 2% is a suitable vehicle for intramuscular administration, however, not for initial reconstitution.