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The blood pressure of uncontrolled hypertension patients will increase after administration of tropisetron HCl, thus, it should be used by hypertension patients with caution with dosage not more than 10 mg/day.
When administered in patients with impaired hepatic or renal function, its t½ will prolong, but no drug accumulation occurs during 6-day courses of 5 mg/day, thus no dosage adjustment is necessary.
Effects on the Ability to Drive or Operate Machinery: The common adverse reactions of tropisetron HCl are dizziness and fatigue, thus, it should be given with caution to patients who drive and operate a machinery after administration.
Use in pregnancy & lactation: The use in pregnant women is not recommended. It is not known whether tropisetron HCl is excreted into human milk and therefore patients receiving the drug should not breastfeed.
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