Hemarate Overdosage

Iron: Symptoms of acute iron overdosage can be divided into four stages.
Stage I: occurs up to six hours after ingestion, the principal symptoms are vomiting and diarrhea. Other symptoms include hypotension (low blood pressure), tachycardia (rapid heartbeat) and central nervous system (CNS) depression ranging from lethargy (sleepiness) to coma (state of unconsciousness).
Stage II: may occur 6 to 24 hours after ingestion and is characterized by a temporary remission or signs of overdosage are decreased.
Stage III: gastrointestinal symptoms recur accompanied by shock, metabolic acidosis (increased acid in the blood), coma, hepatic necrosis (death of liver tissue), jaundice (yellowish color of the skin, eyes and other tissues), hypoglycemia (low blood sugar), kidney failure, and pulmonary edema (fluid in the lungs).
Stage IV: occur several weeks after ingestion and is characterized by gastrointestinal obstruction (blockage) and liver damage.
Pyridoxine (Vitamin B₆): Although vitamin B₆ has generally been considered relatively nontoxic, long term (two months or longer) administration of large (megadose) dosages (usually 2 grams or more daily) of vitamin B₆ can cause neurological symptoms manifested as paresthesia (more noticeable at night and limited to the extremities), bone pains (described as lightning, stabbing or shooting like a knitting needle or electric shocks), hyperesthesia (described as burning, pricking, stinging, or itching), muscle weakness (difficulty in running, lifting, climbing stairs and loss of manual dexterity), fasciculation (described as twitching, restlessness or fidgeting), and numbness on the limbs and face.
Vitamin B₁₂: Use of doses greater than 10 micrograms daily may produce a haematological response in patients with folate deficiency; indiscriminate use may mask the precise diagnosis.
Nicotinamide: Dosages of nicotinamide in excess of 100 mg daily may cause flushing of the face, arms, and chest, itching and nausea.
If the patient has taken more than the recommended dosage, consult a doctor or contact a Poison Control Center right away.