Gouter Mechanism of Action

Antigout.
Pharmacology: Pharmacodynamics: Mechanism of Action: Colchicine reduces neutrophil-mediated inflammatory response by disrupting cytoskeletal functions thereby blocking the β-tubulin polymerisation into microtubules, and preventing the activation, degranulation, and migration of neutrophils into the inflamed area. In familial Mediterranean fever, it may interfere with intracellular assembly of the inflammasome complex present in neutrophils and monocytes which mediates interleukin-1β activation.
Onset: Pain relief: Approximately 18-24 hours.
Pharmacokinetics: Peak plasma concentrations of Colchicine are reached within 2 hours of oral administration. Colchicine is partially deacetylated in the liver and the unchanged drug and its metabolites are excreted in the bile and undergo intestinal reabsorption. Colchicine is found in high concentrations in leucocytes, kidneys, the liver, and spleen. Most of the drug is excreted in the faeces but 10 to 20% is excreted in the urine and this proportion rises in patients with liver disorders.