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Pregnancy: There are no adequate data from the use of sitagliptin in pregnant women. Studies in animals have shown reproductive toxicity at high doses (see Pharmacology: Toxicology: Preclinical Safety Data under Actions). The potential risk for humans is unknown. Due to lack of human data, Sitagliptin (Glyxera) should not be used during pregnancy.
Breast-feeding: It is unknown whether sitagliptin is excreted in human breast milk. Animal studies have shown excretion of sitagliptin in breast milk. Sitagliptin (Glyxera) should not be used during breast-feeding.
Fertility: Animal data do not suggest an effect of treatment with sitagliptin on male and female fertility. Human data are lacking.
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