Glyhart Adverse Reactions

The most frequently reported adverse events with dapagliflozin include female genital mycotic infections, nasopharyngitis, and urinary tract infections.
Infections and infestations: Influenza, nasopharyngitis, upper respiratory infection, fungal infection, female genital mycotic infections (including vulvovaginal mycotic infection, vaginal infection, vulvovaginal candidiasis, vulvovaginitis, genital infection, genital candidiasis, fungal genital infection, vulvitis, genitourinary tract infection, vulval abscess, and vaginitis bacterial), male genital mycotic infections (including balanitis, fungal genital infection, balanitis candida, genital candidiasis, genital infection male, penile infection, balanoposthitis, balanoposthitis infective, genital infection and posthitis), necrotizing fasciitis of the perineum (Fournier's gangrene), urinary tract infections (including urinary tract infection, cystitis, Escherichia urinary tract infection, genitourinary tract infection, urosepsis, pyelonephritis, trigonitis, urethritis, kidney infection and prostatitis).
Immune system disorders: Hypersensitivity reactions (e.g., angioedema, urticaria, hypersensitivity), anaphylactic reactions, severe cutaneous adverse reactions.
Metabolism and nutrition disorders: Diabetic ketoacidosis (when used in type 2 diabetes mellitus), hypoglycemia (particularly when used with insulin or sulfonylureas), dyslipidemia, hyperphosphatemia, thirst, volume depletion (including dehydration, hypovolemia, hypotension/orthostatic hypotension).
Nervous system disorders: Dizziness, headache.
Gastrointestinal disorders: Acute pancreatitis, constipation, diarrhea, dry mouth, nausea.
Skin and subcutaneous tissue disorders: Rash (including rash generalized, rash pruritic, rash macular, rash maculopapular, rash pustular, rash vesicular, and rash erythematous).
Musculoskeletal and connective tissue disorders: Back pain, bone fracture, pain in extremity.
Renal and urinary disorders: Acute kidney injury (including acute renal failure), discomfort with urination, dysuria, nocturia, polyuria (including pollakiuria, polyuria, increased urine output).
Reproductive system and breast disorders: Pruritus genital, vulvovaginal pruritus.
Investigations: Increased hematocrit, serum creatinine, blood urea nitrogen (BUN), total cholesterol, LDL- and HDL-cholesterol; decreased triglycerides, creatinine renal clearance, and glomerular filtration rate; increased serum inorganic phosphorus; decreased serum bicarbonate; weight decreased.