Gliptadin Dosage/Direction for Use

Sitagliptin has a recommended dose of 100 mg once daily as monotherapy or as combination therapy with metformin, a sulfonylurea, insulin (with or without metformin), a PPARγ agonist (e.g., thiazolidinediones), metformin plus a sulfonylurea, or metformin plus PPARγ agonist. When it is used in combination with a sulfonylurea or with insulin, a lower dose of sulfonylurea or insulin may be considered to reduce the risk of sulfonylurea-or insulin-induced hypoglycemia.
Patients with renal impairment: Since there is a dosage adjustment based upon renal function, assessment of renal function is recommended prior to initiation of sitagliptin and periodically thereafter.
Patients with mild renal impairment (estimated glomerular filtration rate [eGFR] ≥60 mL/min/1.73 m² to <90 mL/min/1.73 m²): No dosage adjustment for sitagliptin is required.
Patients with moderate renal impairment (eGFR ≥45 mL/min/1.73 m² to <60 mL/min/1.73 m²): No dosage adjustment for sitagliptin is required.
Patients with moderate renal impairment (eGFR ≥30 mL/min/1.73 m² to <45 mL/min/1.73 m²): The dose of sitagliptin is 50 mg once daily.
Patients with severe renal impairment (eGFR ≥15 mL/min/1.73 m² to <30 mL/min/1.73 m²) or with end-stage renal disease (ESRD) (eGFR <15 mL/min/1.73 m²), including those requiring hemodialysis or peritoneal dialysis: Sitagliptin recommended dose is 25 mg once daily and may be administered without regard to the timing of dialysis.
Mode of Administration: Sitagliptin can be taken orally with or without food.