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Genzifen

Genzifen

tamoxifen

Manufacturer:

Rainbow Life Sciences

Distributor:

Genace Pharma

Marketer:

Ambica
Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing
Concise Prescribing Info
Contents
Tamoxifen citrate
Indications/Uses
Breast cancer.
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Dosage/Direction for Use
Adult including elderly 20-40 mg daily in divided doses bid or as single dose once daily.
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Overdosage
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Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Pregnancy.
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Special Precautions
Suppressed menstruation. Increased incidence of endometrial cancer & uterine sarcoma. May affect development of endometrial pathology including neoplasia. 2nd primary tumors. May increase risk of microvascular flap complications in delayed microsurgical breast reconstruction. Avoid concomitant use w/ potent CYP2D6 inhibitors eg, paroxetine, fluoxetine, quinidine, cinacalcet or bupropion. Not to be taken by patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. May affect ability to drive & use machines. Sexually-active women should use barrier or other non-hormonal contraception. Not recommended during lactation. Not recommended in childn.
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Use In Pregnancy & Lactation
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Adverse Reactions
Fluid retention; hot flushes; nausea; skin rash; vag bleeding & discharge; fatigue. Uterine fibroids; anemia; hypersensitivity reactions; ischemic cerebrovascular events, headache, light headedness, sensory disturbances (including paresthesia & dysgeusia); cataracts, retinopathy; vomiting, diarrhea, constipation; changes in liver enzymes, fatty liver; alopecia; leg cramp, myalgia; pruritus vulvae, endometrial changes (including hyperplasia & polyps); elevated triglycerides; thromboembolic events (including DVT, microvascular thrombosis & pulmonary embolism).
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Drug Interactions
Increased anticoagulant effect of coumarin-type anticoagulants. Increased risk of thromboembolic events w/ cytotoxic agents. Reduced plasma levels w/ CYP3A4 inducer eg, rifampicin. Reduced efficacy w/ SSRI antidepressants (eg, paroxetine) & potent CYP2D6 inhibitors (eg, paroxetine, fluoxetine, quinidine, cinacalcet or bupropion).
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Storage
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Description
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Action
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MIMS Class
Cancer Hormone Therapy
ATC Classification
L02BA01 - tamoxifen ; Belongs to the class of anti-estrogens. Used in treatment of neoplastic diseases.
Regulatory Classification
Rx
Presentation/Packing
Form
Genzifen FC tab 20 mg
Packing/Price
30's