Gastriv Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Omeprazole

Indications/Uses

Conditions where inhibition of gastric acid secretion may be beneficial including aspiration syndromes, dyspepsia, erosive esophagitis, GERD, benign gastric ulcer, duodenal ulcer, & hypersecretory conditions (eg, Zollinger-Ellison syndrome).

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Dosage/Direction for Use

Dyspepsia 20 mg daily for 2-4 wk. GERD 20 mg once daily for 4 wk; some may require additional 4 wk of therapy. Refractory esophagitis 40 mg daily. Maintenance therapy: 20 mg once daily after healing of esophagitis. Childn Dose range: 0.7-1.4 mg/kg daily, up to max dose of 40 mg, have been given for 4-12 wk. PUD Single dose of 20 mg, or 40 mg in severe cases. Treatment is continued for 4 wk for duodenal ulcer & 8 wk for gastric ulcer. Where appropriate, dose of 20 mg once daily may be given for maintenance. NSAID-associated ulceration 20 mg once daily. Zollinger-Ellison syndrome Initially 60 mg once daily. Prophylaxis of acid aspiration during general anesth 40 mg in evening before surgery & 40 mg on the day of surgery, 2-6 hr before the procedure.

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Overdosage

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Administration

Should be taken on an empty stomach.

Contraindications

Hypersensitivity to omeprazole or substituted benzimidazoles.

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Special Precautions

Consider possibility of malignancy in patients w/ gastric ulcers before giving omeprazole & other PPIs since these drugs may mask symptoms & delay diagnosis. Increased risk of GI infection. Caution in patients w/ hepatic impairment.

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Use In Pregnancy & Lactation

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Adverse Reactions

Headache, diarrhea, skin rashes. Pruritus, dizziness, fatigue, constipation, nausea, vomiting, flatulence, abdominal pain, arthralgia, myalgia, urticaria, dry mouth.

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Drug Interactions

May prolong elimination of diazepam, phenytoin, & warfarin. Reduced absorption of drugs (eg, ketoconazole, & possibly itraconazole) whose absorption is dependent on acid gastric pH. May alter metabolism of other drugs metabolized by CYP450, primarily CYP2C19.

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Description

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Action

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MIMS Class

Antacids, Antireflux Agents & Antiulcerants

ATC Classification

A02BC01 - omeprazole ; Belongs to the class of proton pump inhibitors. Used in the treatment of peptic ulcer and gastro-oesophageal reflux disease (GERD).

Regulatory Classification

Presentation/Packing

Form

Gastriv DR cap 40 mg

Packing/Price

50's

Gastriv

omeprazole

Manufacturer:

Hizon

Distributor:

Crisdy-Na