Furic Dosage/Direction for Use

Recommended Dose: For treatment of hyperuricemia in patients with gout. Febuxostat is recommended at 40 or 80 mg once daily. The recommendation starting dose of febuxostat is 40 mg once daily. For patients who do not achieve a serum uric acid <6 mg/dL after 2 weeks with 40 mg, febuxostat 80 mg is recommended.
Febuxostat can be taken without regard to food or antacid use.
Special Populations: No dose adjustment is necessary when administering febuxostat in patients with mild to moderate renal impairment. The recommended starting dose of febuxostat is 40 mg once daily. For patients who do not achieve a serum uric acid <6 mg/dL after 2 weeks with 40 mg, febuxostat 80 mg is recommended.
No dose adjustment is necessary in patients with mild to moderate hepatic impairment.
Uric Acid Level: Testing for the target serum uric acid level of <6 mg/dL may be performed as early as 2 weeks after initiating febuxostat therapy.
Gout Flares: Gout flares may occur after initiation of febuxostat due to changing serum uric acid levels resulting in mobilization of urate from tissue deposits. Flare prophylaxis with a nonsteroidal anti-inflammatory drug (NSAID) or colchicine is recommended upon initiation of febuxostat. Prophylactic therapy may be beneficial for up to 6 months.
If a gout flare occurs during febuxostat treatment, febuxostat need not be discontinued. The gout flare should be managed concurrently, as appropriate for the individual patient.