Fucidin Mechanism of Action

Ointment: Pharmacology: Pharmacodynamics: Fucidin ointment 2% contains Sodium Fusidate, a potent topical antibacterial. Fusidic acid and its salts exhibit fat and water solubility properties with strong surface activity, and show unusual ability to penetrate intact skin. However, they are poorly systemically absorbed after topical administration.
Concentrations of 0.03 - 0.12 mcg/ml inhibit nearly all strains of Staphylococcus aureus. Topical Fucidin is also active against Streptococci, Corynebacteria, Neisseria and certain Clostridia.
Pharmacokinetics: There are no data which define the pharmacokinetics of Fucidin Ointment, following topical administration in man.
However, in-vitro studies show that fusidic acid and its salts can penetrate intact human skin in concentrations well above the MIC value of susceptible organisms.
The degree of penetration depends on factors such as the duration of exposure to fusidic acid (or its salts) and the condition of the skin. Fusidic acid and its salts are excreted mainly in the bile with little excreted in the urine.