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The safety of Piroxicam + Methyl Salicylate + Menthol + Eugenol (FlanaxPlus) during pregnancy or lactation has not been established.
This effect, as with other non-steroidal anti-inflammatory agents has been associated with an increased incidence of dystocia and delayed parturition in pregnant animals when piroxicam administration was continued into late pregnancy. Non-steroidal anti-inflammatory drugs are also known to induce closure of the ductus arteriosus in infants.
A preliminary study indicates the following oral administration, piroxicam exists in maternal milk in a concentration of approximately 1% of that reached in plasma after oral administration. Piroxicam + Methyl Salicylate + Menthol + Eugenol (FlanaxPlus) is not recommended for use in nursing mothers as the clinical safety has not been established.
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