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It is contraindicated in patients with severe heart failure, inflammatory bowel disease and renal impairment associated with a creatinine clearance of less than 30 mL per minute.
It is also contraindicated in patients with asthma and urticaria.
Absolute Contraindication: Not to be given to those patients who have a history of: Stroke, Cerebrovascular Accident (CVA); Heart Attack, Myocardial Infarction; Coronary Artery Bypass Graft (CABG); Uncontrolled Hypertension; Congestive Heart Failure (CHF), NYHA II-IV.
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