Adults: The recommended dose of Cefixime trihydrate (Fixbact) is 400 mg daily. This may be given as a 400 mg tablet daily or as 200 mg tablet every 12 hours. For the treatment of uncomplicated cervical/urethral gonococcal infections, a single oral dose of 400 mg is recommended.
Children: 8 mg/kg body weight daily as a single or 2 divided doses. Not recommended for children below 6 months of age. Children weighing more than 50 kg or older than 12 years should be treated with the recommended adult dose. Otitis media should be treated with the suspension. Efficacy and safety in infants aged less than six months have not been established. In the treatment of infections due to S. pyogenes, a therapeutic dosage of Cefixime trihydrate (Fixbact) should be administered for at least 10 days or as prescribed by the physician.
Renal Impairment: Cefixime trihydrate (Fixbact) may be administered in the presence of impaired renal function. Normal dose and schedule may be employed in patients with creatinine clearances of 60 mL/min or greater. Patients whose clearance is between 21 and 60 mL/min or patients who are on renal hemodialysis may be given of the 75% standard dosage at the standard dosing interval (ie, 300 mg daily). Patients whose clearance 20 mL/min, or patients who are on continuous ambulatory peritoneal dialysis may be given half the standard dosage at the standard dosing interval (ie, 200 mg daily). Neither hemodialysis nor peritoneal dialysis remove significant amounts of drug from the body.
DIRECTIONS FOR USE: Take each dose with a full glass of water. Take Cefixime trihydrate (Fixbact) with food or milk if it causes stomach upset. Continue taking the medication till the prescribed course is complete.
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