Gout Flare: An increase in gout flares is frequently observed during initiation of anti-hyperuricemic agents, including Febuxostat (Febulas). If a gout flare occurs during treatment, Febuxostat (Febulas) need not be discontinued. Prophylactic therapy (i.e., non-steroidal anti-inflammatory drug [NSAID] or colchicine upon initiation of treatment) may be beneficial for up to six months.
Cardiovascular Events: Monitor for signs and symptoms of MI and stroke and discuss with physician.
Use in Children: Safety and effectiveness of Febuxostat (Febulas) in pediatric patients have not been established.
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